Top 10 Best Nasal Sprays for Allergies | Buoy (2025)

Nasal sprays are an effective solution for alleviating allergy symptoms by reducing swelling and clearing mucus directly in the nasal passages where irritation from allergens often occurs. Some of them work within 15 minutes after use. Their localized treatment minimizes side effects compared to oral medications and provides fast, effective relief at the source of the problem.

This article will discuss the 10 best nasal sprays to help relieve allergy symptoms. We’ll also discuss what makes each suitable and how they can help you feel better.

Types of Nasal Sprays for Allergies

Nasal sprays are liquid medications squirted into the nasal passages to alleviate nasal congestion commonly caused by colds or allergies. They work by relieving stuffiness and reducing nasal discharge. These sprays deliver the medication in a fine mist, released from a pressurized container with a valve for adequate symptom relief.

​​There are a variety of nasal sprays on the market with different mechanisms of action. Knowing the differences is essential in making an informed choice on allergy relief. Here are the different types of nasal sprays that combat allergy symptoms.

1. Antihistamine Sprays

These sprays target nasal allergy symptoms by blocking histamine. Common side effects of antihistamine nasal sprays include the following:

  • Bitter taste
  • Dizziness
  • Drowsiness
  • Dry mouth and nose

You can get these with a prescription; some are also available over the counter. Prescription options include the following medications:

  • Patanase (Olopatadine)
  • Astelin (Azelastine)

An example of an OTC antihistamine is Astepro (the OTC version of Astelin)

2. Steroid Nasal Sprays

These are preferred for various allergy symptoms, especially for reducing inflammation and congestion. They work best when used regularly, typically once daily for a few weeks.

Common side effects of using steroid nasal sprays include the following:

  • Headaches
  • Nosebleeds
  • Nasal irritation
  • Cough

If you've had nose surgery, an untreated sinus infection, tuberculosis, or if you're pregnant or breastfeeding, talk to a doctor before using steroid nasal sprays.

Examples of steroid nasal sprays in the market are:

  • Rhinocort (Budesonide)
  • Flonase (Fluticasone)
  • Nasonex (Mometasone)
  • Nasacort (Triamcinolone)
  • Veramyst (Fluticasone furoate)

3. Mast Cell Inhibitor Sprays

Mast cell inhibitor nasal sprays work by helping prevent the release of histamine, reducing allergy symptoms when used consistently. They help control allergic reactions over time but don't provide quick relief. Still, they're essential for long-term allergy management.

Typical side effects are the following:

  • Sneezing
  • Nasal burning or irritation
  • Unpleasant taste

Given their safety profile, mast cell inhibitor sprays suit many users, including children and adults.

An example of a mast cell inhibitor nasal spray available OTC is Cromolyn sodium (Nasalcrom).

4. Decongestant Sprays

Decongestant nasal sprays provide immediate relief for nasal congestion but should be used short-term to avoid rebound congestion. It is generally advisable to avoid use beyond 3-4 consecutive days before taking a break from use.

These sprays shrink blood vessels in the nose to lessen congestion, but they don't stop sneezing or a runny nose. They give quick relief and are often used for sudden nasal blockage.

Common side effects associated with decongestant sprays are the following:

  • Sneezing
  • Nausea
  • Sinus pains
  • Vomiting
  • Dryness or burning in the nose
  • Rebound congestion with prolonged use, which can be difficult to treat

Contraindications for decongestant sprays include individuals who have the following conditions:

  • Cardiovascular conditions, such as high blood pressure or heart disease
  • Overactive thyroid or enlarged prostate
  • Pregnant women should consult a doctor before use

Some of the decongestant nasal sprays found on the market are the following:

  • Afrin (Oxymetazoline)
  • Zicam (Oxymetazoline)
  • Sinex (Oxymetazoline)
  • Dristan (Phenylephrine)
  • Neo-Synephrine (Phenylephrine)

5. Saline Sprays

Saline nasal sprays moisturize the nasal passages, which helps to thin mucus and moisturize the nasal lining. They can be used without side effects except for possible mild irritation.

Common side effects are minimal but can include the following:

  • Mild nasal irritation
  • A brief stinging sensation if the nasal passages are very dry

Examples of saline nasal spray products include the following:

  • Arm & Hammer Simply Saline (Sodium chloride, sodium bicarbonate)
  • Ayr (Sodium chloride 0.65%)
  • Amazon Basic Care Premium Saline Nasal Moisturizing Spray
  • Ocean nasal

6. Anticholinergic Sprays

Anticholinergic nasal sprays help dry up a runny nose by blocking acetylcholine, making them effective for allergic and nonallergic rhinitis.

Side effects associated with anticholinergic sprays can include the following:

  • Dryness of the nasal mucosa
  • Irritation or burning sensation in the nose
  • Headache
  • Dry mouth

People with narrow-angle glaucoma or trouble urinating should be careful with anticholinergics, and they're recommended for children.

The market offers Atrovent (Ipratropium bromide, 0.03%) as a prescription anticholinergic nasal spray. There are no OTC anticholinergic nasal sprays available.

Top 10 Best Nasal Sprays for Allergies

We understand the importance of effective allergy relief, especially in wanting to feel comfortable doing daily tasks without allergy symptoms. That's why we have meticulously researched and compiled a list of the top 10 best nasal sprays for allergies.

Our selection is based on carefully evaluating factors such as the following:

  • Efficacy
  • Active Ingredient
  • Potency
  • Each of administration
  • Potential side effects

Whether you're seeking immediate relief from acute symptoms or a long-term solution for managing your allergies, our top recommendations are detailed below.

Top 10 Best Nasal Sprays for Allergies | Buoy (2025)

FAQs

What is the most effective allergy nasal spray? ›

Over-the-counter (OTC) steroid and antihistamine nasal sprays work best to treat allergy symptoms. Flonase Allergy Relief (fluticasone), Nasacort Allergy 24 Hour (triamcinolone), and Astepro Allergy (azelastine) are common examples. They're safe for both adults and children for daily use.

What nasal sprays do doctors prescribe? ›

They're often the first drug recommended for allergies, but it takes about a week before you'll notice your symptoms getting better. Examples of steroid nasal sprays available by prescription include beclomethasone (Beconase, Qnasl), ciclesonide (Zetonna), fluticasone furoate (Veramyst), and mometasone (Nasonex).

What is the best medicine for nose allergies? ›

  • Brompheniramine-pseudoephedrine (Brotapp, Rynex PSE)
  • Cetirizine-pseudoephedrine (ZyrTEC-D Allergy & Congestion)
  • Chlorpheniramine-pseudoephedrine (SudoGest)
  • Fexofenadine-pseudoephedrine (Allegra-D)
  • Loratadine-pseudoephedrine (Claritin-D, Alavert Allergy and Sinus)
Mar 6, 2024

What nasal spray can I use every day? ›

Nasal steroids sprays (Flonase®, Nasocort®, Nasonex®, etc. ) are safe to use on a daily basis and are now largely over-the-counter. These sprays are non-addictive and typically do not cause any long term changes to the nasal passages.

What's better than Flonase? ›

Official answer. Nasacort and Flonase are equally effective, safe, and well tolerated for the treatment of allergic rhinitis. Therefore the choice of either Nasacort or Flonase comes down to personal preference, availability or price.

What nasal spray has the least side effects? ›

Of the different types of allergy nasal sprays, saline nasal spray is known to cause the fewest side effects because it does not contain any medication.

What is the downside of Flonase? ›

Nasal side effects — such as nosebleeds, irritation, and burning — can happen, too. Most side effects are generally mild and can be managed at home. Serious Flonase side effects include vision changes, asthma symptoms, and thrush. Discuss these risks with your healthcare provider or pharmacist before using Flonase.

What is the name of the new nasal spray for allergies? ›

Today, the U.S. Food and Drug Administration approved neffy (epinephrine nasal spray) for the emergency treatment of allergic reactions (Type I), including those that are life-threatening (anaphylaxis), in adult and pediatric patients who weigh at least 30 kilograms (about 66 pounds).

Why was Flonase taken off the market? ›

The nasal spray has been found to contain small glass particles which could block the actuator and impact the functionality of the pump. There is a potential for patients to be exposed to the glass particles and mechanical irritation cannot be ruled out.

What is the best allergy medicine for severe allergies? ›

Antihistamines, such as Claritin (loratadine), can provide quick relief and can help prevent symptoms if taken every day. Nasal steroids, such as Flonase (fluticasone propionate), are generally the most effective allergy medicines but can take up to 2 weeks to fully work.

What is the strongest antihistamine? ›

What is the most effective antihistamine? Among second-generation antihistamines, Zyrtec is the strongest and most effective, says Dr. Staiger. The first-generation antihistamine Benadryl is also highly effective, but drowsiness is a limiting factor (unless you are looking to utilize it as a sleep aid), he says.

How do I get rid of sinus allergies permanently? ›

While there is no permanent cure for allergic rhinitis, you can manage your symptoms effectively at home by using a combination of home remedies and over-the-counter medications. Steam inhalation, saline nasal irrigation, and the use of essential oils can help alleviate symptoms.

What is the most effective nasal spray for allergies? ›

Experts say that over-the-counter (OTC) anti-inflammatory nasal sprays—such as FLONASE nasal sprays or Nasacort® 24 Hour—are the most effective form of nasal allergy symptom relief.

What spray is good for allergic rhinitis? ›

Nasal corticosteroid sprays are the most effective treatment for allergic rhinitis. They work best when used nonstop, but they can also be helpful when used for shorter periods of time. They can even help when used intermittently. Corticosteroid sprays are generally safe for children and adults.

Which is better, Nasonex or Nasacort? ›

Timing: Nasonex may take a few days to work, while Nasacort may provide quicker relief. How often to use: Nasonex is typically used once a day, while Nasacort can be used once or twice a day. Side effects: Both may cause mild side effects like nasal irritation or headache, but the specific side effects can vary.

Which allergy medicine is best for nasal congestion? ›

Nasal steroids generally take longer to work than antihistamines. But healthcare providers consider them to be the most effective for keeping nasal allergy symptoms in check over time. As a group, they may also be more effective at preventing nasal congestion compared to antihistamines.

Is Afrin or Flonase better for allergies? ›

One common misperception when choosing a nasal allergy spray is that all nasal sprays are created equal. However, this is not true. For example, nasal sprays such as Afrin® are only decongestants, while FLONASE allergy relief nasal sprays offer more complete* relief by treating additional nasal allergy symptoms.

Which is better, Flonase or Nasonex? ›

Official answer. The difference is Flonase is available over-the-counter (OTC) and Nasonex is prescription only. There is no difference in their effect or side effects. Flonase and Nasonex are both corticosteroid nasal sprays that are effective at treating hay fever, perennial allergic rhinitis and allergies.

References

Top Articles
Latest Posts
Recommended Articles
Article information

Author: Allyn Kozey

Last Updated:

Views: 6722

Rating: 4.2 / 5 (43 voted)

Reviews: 82% of readers found this page helpful

Author information

Name: Allyn Kozey

Birthday: 1993-12-21

Address: Suite 454 40343 Larson Union, Port Melia, TX 16164

Phone: +2456904400762

Job: Investor Administrator

Hobby: Sketching, Puzzles, Pet, Mountaineering, Skydiving, Dowsing, Sports

Introduction: My name is Allyn Kozey, I am a outstanding, colorful, adventurous, encouraging, zealous, tender, helpful person who loves writing and wants to share my knowledge and understanding with you.